Oral Dose vs IV

Most people take dietary supplements delivered by pills, softgels or powders, but they are also provided by medical personnel through intravenous (IV) injections. Research shows it’s a faster delivery form (Boretti A, Krishna B, 2020).

There are many different health conditions that increase cellular oxidative stress causing cells to dysfunction and can lead to organ problems. Therefore, health practitioners may choose supplements administered through IV feedings instead of oral doses to deliver the material faster.

IV’s are provided directly into a vein using a needle or tube. This type of procedure is performed only by a licensed medical practitioner. With IV administration, the healthcare provider uses a narrow plastic tube called an IV catheter inserted into the vein. 

Vitamin C and other nutritional supplements have been shown to provide supportive therapy especially when provided intravenously (IV) (Boretti A, Krishna B, 2020). Research has demonstrated that Vitamin C (500 mg) provided via IV administration showed a higher blood concentration of ascorbate and was more effective than oral dosing (Boretti A, Krishna B, 2020). Vitamin C has also been combined with other nutrients such as magnesium administered through IV to increase the vitamin C uptake activity (Cho S et al, 2020). 

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme that is found in every cell of the body and involved in metabolism. It is important for maintenance of DNA and protects against cell damage. As one ages, NAD levels diminish, therefore it has been proposed to administer NAD+ either by supplements or by IV therapy since it is believed to be the best method to increase NAD+ levels (Grant R et al, 2019).

A clinical study was performed over a 6 hour period evaluating the changes in human plasma and urine after providing an Intravenous Infusion of NAD+ (Grant R et al, 2019). The study showed that in the first 2 hours NAD+ is quickly and completely utilized. There were no adverse events reported during the IV administration over the 6 hour period for the NAD+ and placebo groups.

Vitamin D was administered intravenously over a 5 week animal study to evaluate its uptake (Greilberger J et al, 2019). There was no toxicity observed and there was a significant increase of the vitamin D levels without any changes in electrolytes or white blood cells. 

There are safety issues with IV administration delivering different compounds and there may be some adverse effects including allergy reactions. For that reason, it is important to talk to a health care practitioner prior to IV infusion. 

In summary, dietary supplements are delivered through oral dosing of pills, softgels or powders, but health practitioners deliver them also through IV injections since it has been shown to be faster way to deliver. Vitamin C and D and NAD+ are a few that have been studied showing their benefits. There are some safety issues, therefore it is always best to discuss with your health care provider before having it performed.