NAD Precursors: What Is NAD+ And Why Do We Need It?

It’s said that without Nicotinamide Adenine Dinucleotide (NAD) we are dead in 30 seconds and that’s because NAD is responsible for cellular energy metabolism.  Essentially it converts the food we eat into energy and as a natural part of the aging process the older we get the less NAD our body produces.

In fact, there are numerous studies that link low levels of NAD with health-related problems and mitochondrial dysfunction.  So if you are lacking energy, getting tired faster, find physical activity more difficult, having trouble sleeping, and your skin is looking kinda old, it’s about time you look at your cellular health.

“Without Nicotinamide Adenine Dinucleotide we are dead in 30 seconds”

David Sinclair

Fortunately, supplements containing precusors are readily available and the research is very promising.  Although you’d think the best way to supplement cellular health and boost NAD levels would be to increase your intake of NAD or to supplement with a direct form that’s not necessarily the case.  That’s because NAD in its purest form is too large to be absorbed directly into cells. Precursors on the other hand efficiently convert, absorb, and supercharge cellular health.

Interestingly, there are other ways to boost NAD levels: exercise and fasting.  It goes without saying, if you are serious about improving lifespan, diet and exercise should always be the first area you look to improve.  But if you want to dramatically boost NAD levels (up to 50%) you need to be supplementing with a precursor.

More specifically, Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) are the leading precursors on the market.  There are other options like Vitamin B3: Niacinamide, Nicotinamide, and Niacin but none of these are as efficient or they negatively interact with longevity genes.  We’ll talk about longevity genes (AKA Sirtuins) in greater detail in later posts, but an added benefit of boosting NAD is that it activates longevity genes.        

  • Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) are the leading precursors on the market
  • Vit B3 derivitives are precursors as well but are not as efficient and interfere with Sirtuins
  • NAD Precursors activate longevity genes

If you’re not yet convinced precursors are a necessary addition to your daily regime, there’s one more thing to consider.  NMN and NR are believed to be exercise and calorie restriction mimetics. Or as they say, exercise in a pill: