As the calendar turns to a new decade, we look forward to gene editing, gene therapy, CRISPR, and artificial intelligence. Although these technologies have already arrived society has yet to decide on the ethical implications or full advancements are simply not yet fully realized. It’s very true that these technologies will have a tremendous effect on longevity & aging, our focus however, is a bit more tangible and accessible.

At we are evangelists on fire looking to share the gospel on longevity supplementation and diet. You can expect the latest news and insights on Precursors, Sirtuins, Mimetics, Senolytics, and Fasting. If you are familiar with these topics, you can expect to find unbiased information on NMN, NR, Resveratrol, Sirtuins, Calorie Restriction, and David Sinclair. Really anything in regards to longevity and aging but the common theme will likely circle back per above.

NAD Precursors, Sirtuins, Mimetics — Oh My!!!

Ok so we’ll get into specifics on NAD Precursors in future posts but for the sake of simplicity we’re talking mainly about Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). We’ll detail NADH, NAD, and nicotinamide later on but NMN and NR are definitely getting the longevity love of late.

Sirtuins, AKA longevity genes, have been in the news for awhile but some conflicting studies over the years put their benefit in doubt. Fortunately, the questions have been answered and this longevity pathway is something we’ll definitely talk a lot about. Interestingly, as we put this all together, we’ll find out how precursors, sirtuins, and mimetics work synergistically with one another for their longevity benefits.

Meanwhile, the subject getting the least amount of attention of the three that’s trending of late are mimetics. More specifically, Exercise and Calorie Restriction Mimetics (CRM). Essentially there are molecules that mimic the anti-aging effects of exercise and calorie restriction on a cellular level. We’ll dig deep into the ingredients that are readily available offering such benefits.

So to recap, our blog will primarily focus on the following:

  • NAD Precursors: Nicotinamide Mononucleotide (NMN) & Nicotinamide Riboside (NR).
  • Sirtuin Compounds: Resveratrol, Pterostilbene, Catechins.
  • Exercise & Calorie Restriction Mimetics.

Here is a teaser video with some great content! Featuring David Sinclair, the father of Sirtuins, bringing it all together. This is some exciting stuff! Increased longevity & healthspan to all!

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