The Human Genome Project gave us the source code of life.  Unfortunately, when the project was completed in 2003, we quickly realized nobody knew how to read the source code!  Not surprisingly, this gave rise to the Human Epigenome Project and our digital biology.

You see, the Human Genome Project provided the blueprint for life, but the epigenome tells us how it’s executed.  Because our DNA is essentially the same in every cell, the epigenome has to decide which genes to express. Researchers believe understanding the epigenome and what genes are switched on and off may help us prevent disease and reverse aging.

The Human Genome Project … ‘provided the blueprint for life, but the epigenome will tell us how this whole thing gets executed’.

In fact, MIT believes aging is caused by the loss of epigenetic information and that we can reprogram cells to be young again.  With their focus on longevity genes, AKA Sirtuins, researchers are actively developing Sirtuin Activating Compounds (STACs) and NAD+ boosting molecules.

Researchers have found 3 primary ways to boost the Sirtuin cofactor NAD+:

Exercise & Calorie Restriction Mimetics

Not surprisingly, diet and exercise are linked to longevity and boosting levels of NAD.  Interestingly, though, NAD Boosters such as NR, NMN, etc, have been shown to mimic the effects of exercise and calorie restriction (CRMs) by boosting NAD and activating Sirtuins through stress signaling pathways (hormesis).  Essentially with hormesis, cells move from active growth and proliferation to a state of maintenance and repair.!po=22.7273

The research is clear, caloric restriction and exercise delays aging.  And now thanks to digital biology researchers are able to reprogram cells and deploy helper molecules that mimic the effects of exercise and calorie restriction.!po=9.25926

The discovery of longevity genes showed that it is possible to greatly slow the pace of aging and disease by manipulating just one central pathway. This raises the possibility that we can find small molecules that can treat multiple, seemingly unrelated diseases, with a single medicine.

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